Professor Sheldon M. Schuster earned his Ph.D. from the University of Arizona for work on pyruvate metabolism with Dr. Merle Olson. He joined Dr. Henry A. Lardy at the University of Wisconsin as a Postdoctoral Fellow for studies on mitochondrial ATP synthase. In 1976, he joined the faculty of the University of Nebraska where he rose to the rank of Professor. He served as a member of the NIH Medical Biochemistry Study Section.
Dr. Schuster joined the faculty of the University as Professor and Director of the Interdisciplinary Center for Biotechnology Research in 1989, and in 1992 became Director of the Biotechnology Program.
Research Interests: Our studies are aimed at understanding the relation between structure and function of ATP Synthase and asparagine synthetase. Each system exhibits different facets of enzyme mechanism, and each provides the basis for the design of molecules with therapeutic action. We are expressing the genes for these enzymes and producing mutants to characterize their catalytic function. These studies have revealed a new mechanism for the transfer of amide nitrogen in biological systems and suggest new targets for synthesis of mechanism-based inhibitors of disease related enzymes.